Hydrate Support is based on betaine, also known as trimethylglycine or TMG. Betaine is a short chain, neutral, amino acid derivative that occurs naturally in plants such as linseeds, beets, cereals, horses and us. According to Dr Eleanor Kellon VMD, betaine can help horses that are difficult to hydrate and can support muscle bulk and function, as well as heat tolerance and endurance. It is one of the organic renal osmolytes, a nonmineral which helps maintain a water drawing effect in the kidney. When salt supplementation is not enough, Hydrate Support can help conserve water.
In studies on people and other animals, betaine has been found to maintain the intracellular osmotic pressure similar to other electrolytes. By exhibiting little or no binding to protein surfaces, betaine allows cells to control the surface tension of water, stabilising both protein structure and function. It thereby protects cells, proteins, and enzymes subjected to osmotic stress. This is particularly relevant in the kidney due to its high concentration of electrolytes and urea. Another major feature of betaine is that it donates its methyl group to the toxic metabolite, homocysteine, converting it to the amino acid, methionine.Â
In people with acute anterior poliomyelitis, betaine treatment led to a substantial rise in the motor unit activity and recovery of residual power in weakened muscle, which resulted in improved sense of wellbeing, less fatigue, and greater strength and endurance during treatment.
Safe for laminitic prone or insulin resistant (IR)/EMS horses.
Hydrate Support can be fed with any of the mineral mixes, Equine Amino, Postbiotic Gut Support and the toxin binders Elitox and Mycosorb A+ in the same feed.
Hydrate Support is a nutritional supplement product for inclusion in horse’s feed. Product has no therapeutic effect and is designed to be administered in a feed for voluntary ingestion for horses.
Animal consumption only.
Feeding rate is 15 – 30 g per day for a 500 kg horse, mix with feed.
If feeding twice per day, split between both feeds.
In the beginning, introduce a tiny amount and build up gradually over days. Some picky eaters will reject a feed purely due to a change in flavour. Allow time for the palate to adjust.
In this study, enhanced lactate clearance after exercise, no biochemical effects during exercise, no testing of ergogenic potential (enhancement of physical performance) per se.
Warren LK, Lawrence LM and Thompson KN. (1999)
The influence of betaine on untrained and trained horses exercising to fatigue
https://www.ncbi.nlm.nih.gov/pubmed/10229364
Warren et al discuss muscle fatigue and state that lactic acid accumulation is the cause, this specific cause of fatigue has been disproved. One theory is that phosphate, which increases during fatigue due to breakdown of creatine phosphate, appears to be a major cause of muscle fatigue.
Armstrong LE, Casa DJ, Roti MW, Lee EC, Craig SA, Sutherland JW, Fiala KA and Maresh CM (2008) Influence of betaine consumption on strenuous running and sprinting in a hot environment
https://www.ncbi.nlm.nih.gov/pubmed/18438230
Hoffman JR, Ratamess NA, Kang J, Gonzalez AM, Beller NA and Craig SA (2011)
Effect of 15 days of betaine ingestion on concentric and eccentric force outputs during isokinetic exercise
https://www.ncbi.nlm.nih.gov/pubmed/21747291
Hoffman JR, Ratamess NA, Kang J, Rashti SL and Faigenbaum AD (2009)
Effect of betaine supplementation on power performance and fatigue
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651845/
Lee EC et al (2010)
Ergogenic effects of betaine supplementation on strength and power performance
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915951/
Moeckel GW, Lai LW, Guder WG, Kwon HM and Lien YH (1997)
Kinetics and osmoregulation of Na(+)-and Cl(-)-dependent betaine transporter in rat renal medulla
https://www.ncbi.nlm.nih.gov/pubmed/9039055
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